ITGA6+ Human Testicular Cell Populations Acquire a Mesenchymal Rather than Germ Cell Transcriptional Signature during Long-Term Culture

ITGA6+ Human Testicular Cell Populations Acquire a Mesenchymal Rather than Germ Cell Transcriptional Signature during Long-Term Culture

Autologous spermatogonial stem cell transplantation is an experimental method aimed toward restoring fertility in infertile males. Though efficient in animal fashions, in vitro propagation of human spermatogonia previous to transplantation has confirmed to be troublesome. A significant limiting issue is endogenous somatic testicular cell overgrowth throughout long-term tradition. This makes the tradition each inefficient and […]

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